Acthar is a prescription medicine to be used as a short-term, add-on therapy in the event of symptoms suddenly worsening (flare) for rheumatoid arthritis, including juvenile rheumatoid arthritis. Some cases may require maintenance therapy.

Make the Most of Your Treatment

Read the information below to learn about what to do before, during, and after your Acthar treatment.

Before injecting

Tell your doctor if you’re taking other medications while using Acthar. Continue any current treatments as prescribed unless your doctor says otherwise.

Temperature considerations

Acthar requires special handling. Keep it refrigerated at 36°F to 46°F (2°C to 8°C) until you’re ready to use it. Do not inject Acthar directly after removing it from the refrigerator.

Before you inject, you should warm the vial of Acthar to room temperature. You can do this by rolling it between your hands or by holding it under your arm for a few minutes.

Things to remember

Here are some suggestions for choosing where to inject:

  • Ask your doctor or nurse which injection areas may be best for you
  • When injecting yourself, the muscle along the upper-outer thigh may be best. If someone else is injecting, the muscle in the upper arm may be best
  • You can inject into the same area more than once a week, but rotate the injection sites in that area each time, keeping 1 inch between sites

For more information about injecting Acthar, including videos and downloadable instructions, go to the How to Take Acthar page.

Do not inject into:

  • The same site more than once a week
  • An area that has skin irritation or cuts
  • An area that has hardened or is sensitive to touch
  • Tattoos, warts, scars, or birthmarks
  • The stomach
  • The knee or groin area

Contact your doctor if you notice any injection site reactions, including redness, pain, and swelling.

Do not do the following with any used supplies:

  • Reuse syringes, needles, or vials
  • Throw the syringes, needles, or vials in household trash
  • Recycle syringes, needles, or vials
  • Use a clear plastic or glass container for disposal

Things to keep in mind while taking Acthar

What if I miss a dose of Acthar?

  • Talk with your doctor as soon as you realize that you missed a dose
  • Your doctor will let you know when to take the next dose
  • If you have questions about your Acthar dose, talk to your doctor

Can I take other medications while taking Acthar?

  • Continue taking your other treatments as prescribed by your doctor
  • Tell your doctor about any other health conditions you may have or medicines you are taking, including prescriptions

Things to keep in mind before ending Acthar treatment

Even if you’re feeling better, do not stop taking Acthar without consulting your doctor. If you consider ending treatment before your full course is over, be sure to talk with your doctor as well.

Your doctor will talk to you about when and how to stop treatment with Acthar. He or she may tell you how to gradually reduce the dose and frequency of injections. Do not suddenly stop taking Acthar without talking to your doctor first.


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Call 1-877-546-7228


Learn about educational resources


DO NOT take Acthar until you have talked to your doctor if you have any of the following conditions:

  • A skin condition called scleroderma
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